Monomeric IgE Stimulates NFAT
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چکیده
منابع مشابه
Long-term oxygen therapy.
Cockcroft S. Monomeric IgE stimulates NFAT translocation into the nucleus, a rise in cytosol Ca2+, degranulation, and membrane ruffling in the cultured rat basophilic leukemia-2H3 mast cell line. J Immunol 2004; 172: 4048–4058. 5 Nunomura S, Gon Y, Yoshimaru T, et al. Role of the Fc (varepsilon) RI (b)-chain ITAM as a signal regulator for mast cell activation with monomeric IgE. Int Immunol 200...
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We show in this study that the ability of five different monomeric IgEs to enhance murine bone marrow-derived mast cell (BMMC) survival correlates with their ability to stimulate extracellular calcium (Ca(2+)) entry. However, whereas IgE+Ag more potently stimulates Ca(2+) entry, it does not enhance survival under our conditions. Exploring this further, we found that whereas all five monomeric I...
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NFAT (nuclear factors of activated T cells) proteins constitute a family of transcription factors involved in mediating signal transduction. The presence of NFAT isoforms has been described in all cell types of the immune system, with the exception of neutrophils. In the present work we report for the first time the expression in human neutrophils of NFAT2 mRNA and protein. We also report that ...
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The b-chain of the high-affinity receptor for IgE (FceRI) plays a crucial role for amplification of the intracellular signaling in mast cells upon FceRI cross-linking by IgE antigen complexes (IgE Ag). Some monomeric IgE as well as IgE Ag stimulate FceRI-signaling pathways, leading to cell activation, whereas the biological functions of the b-chain in the monomeric IgE-mediated mast cell signal...
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